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Best Enzymatic Cleaner For Dog Urine of 2025: Top 6 Picks

By Eugene WilliamsLast update: 2024-12-17

Although there are many types of cleaners that can deal with dog urine, you had better choose enzymatic cleaners to solve this problem. Many people think they aren’t as strong as other types of cleaners, but this choice is safe for your lovely pet. If you choose the right enzymatic cleaner for your needs, it can help you remove your dog stains and odors perfectly. Choose the best enzymatic cleaner for dog urine from the list in this article:

Here are the best enzymatic cleaners for dog urine you can buy in 2025:

  • Chlorine Free: Rocco & Roxie Carpet Cleaner Spray
  • Fast Acting: Stuart Pet Enzymatic Cleaner
  • Best For Carpets: ANGRY ORANGE Enzyme Cleaner
  • Best For Hardwood Floor: BUBBAS Commercial Enzyme Cleaner
  • Best For Upholstery: SHOUT Enzymatic Stain And Odor Remover
  • Best For Tough Odor: Sunny & Honey Enzyme Cleaner
6 Best Enzymatic Cleaners For Dog Urine
Chlorine Free
Rocco & Roxie Carpet Cleaner Spray
    Fast Acting
    Stuart Pet Enzymatic Cleaner
      Best For Carpets
      ANGRY ORANGE Enzyme Cleaner
        Best For Hardwood Floor
        BUBBAS Commercial Enzyme Cleaner
          Best For Upholstery
          SHOUT Enzymatic Stain And Odor Remover
            Best For Tough Odor
            Sunny & Honey Enzyme Cleaner

              Chlorine Free: Rocco & Roxie Carpet Cleaner Spray

              Rocco & Roxie Carpet Cleaner Spray
              Rocco & Roxie Carpet Cleaner Spray
              Pros
              • Useful on many types of surfaces
              • Pleasant smell
              • Safe for people and animals
              Cons
              • Quite expensive

              Commonly, chlorine is used in both industry and household cleaning products and they result in impressive performance. However, this ingredient is dangerous to dogs if they expose themselves to this ingredient too much.

              Luckily, the Rocco & Roxie carpet cleaner spray is free of chlorine, so you can use this cleaner for families with children and pets. In particular, it’s safe and soft enough to use for a delicate surface like carpets without ruining it.

              Rocco & Roxie Carpet Cleaner Spray Specifications

              Size

              1 gallon

              Item Form

              Spray

              Highlight Features

              Chlorine free

              Color safe

              Natural enzymes

              Verdict

              The Rocco & Roxie carpet cleaner spray is totally safe to use around your children and pets.

              Fast Acting: Stuart Pet Enzymatic Cleaner

              Stuart Pet Enzymatic Cleaner
              Stuart Pet Enzymatic Cleaner
              Pros
              • Pleasant scent
              • Easy to use
              • Works well for both odors and stains
              Cons
              • Pricey

              If you don’t want to wait as long as other enzymatic cleaners (up to 12-24h), this solution can give you a faster result.

              After applying, this product almost immediately works. Many people think that a fast-acting cleaner isn’t effective with stubborn stains, but this product even can deal with old stains and odors.

              According to customers, you just need to apply this solution on the surface and wait for 5-10 minutes, the odors and stains will be handled after rinsing with hot water.

              Stuart Pet Enzymatic Cleaner Specifications

              Size

              1 gallon

              Item form

              Liquid

              Highlight Features

              Natural enzyme formula

              Use on many surfaces

              Verdict

              The Stuart Pet enzymatic cleaner can quickly give you an excellent result that is very effective.

              Best For Carpets: ANGRY ORANGE Enzyme Cleaner

              ANGRY ORANGE Enzyme Cleaner
              ANGRY ORANGE Enzyme Cleaner
              Pros
              • Good scent
              • Easy to follow instruction
              Cons
              • A little pricey

              Although the manufacturer said that their product can work well on different surfaces, I strongly recommend this cleaner for those who are looking for a suitable solution for a vulnerable surface, like carpets.

              This enzymatic cleaner is formulated from natural ingredients that won’t ruin the soft texture of your carpets. In particular, it leaves a subtle orange scent on the carpet surface.

              ANGRY ORANGE Enzyme Cleaner Specifications

              Size

              32 oz

              Scent

              Fresh Citrus Scent

              Item Form

              Spray

              Highlight Features

              Enzyme-active formula

              Verdict

              The ANGRY ORANGE Enzyme Cleaner helps you get rid of dog urine on your carpets as gently as possible.

              Best For Hardwood Floor: BUBBAS Commercial Enzyme Cleaner

              BUBBAS Commercial Enzyme Cleaner
              BUBBAS Commercial Enzyme Cleaner
              Pros
              • No overpowering scent and great smell
              • No harsh ingredients
              • Environmentally friendly
              • Easy to use
              Cons
              • Potent smell while drying

              When your pet causes accidents on your carpet, almost all liquid absorbs into the fibers of your carpet. Thus, the size of the affected area isn’t big.

              With a smooth hardwood floor, the spills will quickly spread and require you to apply a large amount of cleaner to treat an area at a time.

              The Bubba’s rowdy cleaner at a gallon size is large enough to allow you to handle a large area of an organic spill at a time.

              BUBBAS Commercial Enzyme Cleaner Specifications

              Size

              1 gallon

              Item Form

              Liquid

              Highlight Features

              Natural dormant enzymes


              Verdict

              The BUBBAS Commercial Enzyme Cleaner has an enormous size that allows you to use a large amount for so long.

              Best For Upholstery: SHOUT Enzymatic Stain And Odor Remover

              SHOUT Enzymatic Stain And Odor Remover
              SHOUT Enzymatic Stain And Odor Remover
              Pros
              • Pleasant smell
              • Large bottle for the price
              Cons
              • Not tight bottle

              If you need to remove dog urine stains and odors from your upholstery, the SHOUT enzymatic cleaner is an appropriate solution. After applying, it will deeply penetrate the sub-surface of the fabric to eliminate remaining organics that cause stains and odors. Therefore, this product can stop your dog from remarking on certain areas.

              SHOUT Enzymatic Stain And Odor Remover Specifications

              Size

              32 oz

              Scent

              Fresh Scent

              Item Form

              Spray

              Highlight Features

              Enzymatic formula

              Verdict

              The SHOUT enzymatic stain and odor remover can deeply penetrate to remove the remaining odors and stains in the bottom of upholstery.

              Best For Tough Odor: Sunny & Honey Enzyme Cleaner

              Sunny & Honey Enzyme Cleaner
              Sunny & Honey Enzyme Cleaner
              Pros
              • Great scent
              • No sticky residue
              • Environmentally friendly
              Cons
              • Strong smell with the first application

              For tough odors, chemical products with harsh ingredients can handle them easily, but this choice isn’t safe for your dogs. So, is there any solution that is safe and effective to remove tough odors?

              Sunny & Honey can solve this problem. According to the manufacturer, its bio-enzymatic formula gets rid of 100% of both stains and odors of organic matter. It means that this product allows you to deal with both your dog urine and other wastes.

              Although this cleaner is as powerful and effective as chemical solutions, it’s safer. This cleaner is formulated by high-quality, non-toxic, and bio-enzymatic ingredients.

              With the practical experience, customers said that they can remove an old dog pee odor with this cleaner after trying 3 different products (and failing, of course). Their dog doesn’t notice that position anymore.

              Sunny & Honey Enzyme Cleaner Specifications

              Size

              32 oz

              Scent

              Spring mint scent

              Item Form

              Spray

              Highlight Features

              Only an enzyme-based cleaning solution

              Bio-enzymatic formula

              Verdict

              The Sunny & Honey Enzyme Cleaner can efficiently remove tough and old odors and stains.

              How To Choose The Best Enzymatic Cleaner For Dog Urine?

              Which Ingredients Do A Good Enzymatic Cleaner Have?

              You will use this cleaner around your pets even with children, so you have to choose non-toxic products without containing ammonia and bleach, which worsen the problem of your dog urine in particular areas.

              A good enzymatic cleaner should use eco-friendly enzymes only to break down protein in the stains. Plus, the neutral pH level is powerful enough to fight against odors.

              What Is The Versatility Of Your Enzymatic Cleaner?

              The versatility of an enzymatic cleaner is that which types of messes and kinds of surfaces you can use your enzymatic cleaner on.

              Some just work on carpets, couches, and upholstery while others are more effective on hardwood floors. You can also buy a cleaner that can work on both soft and hard surfaces.

              Read the instructions on the label to make sure that you don’t apply the cleaner on the wrong surface or you can ruin it. While a weak solution can’t solve your problem thoroughly, a too strong cleaner can ruin a delicate surface.

              Do You Want A Cleaner With Fragrances?

              The answer to this question seems to depend on your preference, but you should consider your dog’s feeling. Most of them don’t like these smells.

              If you like odors, it’s better to choose a mild and pleasant smell. Strong smells will overpower pets, causing irritation. In case you are sensitive to smell, buy an odorless or non-scented product.

              Which Type Of Enzyme Cleaner Works Best For You?

              Of course, all types can remove dog urine, but each of them gets rid of other extra waste. Let’s check the information to choose an appropriate product:

              Apart from dog urine, Lipase enzyme cleaner can remove fat and oil-based stains such as grease and oil.

              Amylase enzyme cleaner can eliminate dog urine and starch: sauces, sugar, and eggs.

              Protease enzyme cleaner gets rid of protein-based stains such as blood, wine, and urine.

              How Much Concentration Is Enough?

              The level of concentration helps you determine if your product is a commercial/industrial cleaner or normal cleaner. While the latter removes light stains, the former works well on stubborn stains.

              Will You Choose A Spray Or Pour Bottle?

              Spraying allows you to apply the content more accurately because it’s easier for you to control the amount of cleaner. However, it’s small in size. If you are looking for a good value, you can choose a pour bottle that is larger in size.

              To reach both benefits, buy a pour bottle that allows you to transfer the content into a spray bottle to use the cleaner in a smaller dose.

              Which Surface Do You Need To Clean?

              Basically, most surfaces are divided into 2 types: hard and soft surfaces.

              Some that effectively work on carpets don’t remove stains and odors on hardwood surfaces. Thus, it’s best to check the usage instruction on the label to determine this information for the right application.

              Which Brands Make The Best Enzymatic Cleaner For Dog Urine?

              Nature’s Miracle

              Nature’s Miracle has both online and offline stores, so it’s very easy for you to buy their products. Their regular customers appreciate their products in terms of effectiveness, safety because of their gentle formula, and their pleasant smells.

              Urine Off

              This brand also has stores both online and offline. Their products are well-known for safety for people, pets, and the environment. Of course, this doesn’t decrease their product effects on nasty stains and odors.

              Pawsitively Clean

              This is a Bissell brand, providing their customers with good enzymatic cleaners and other products in the pet care category. It’s easy for you to buy their products online and in stores.

              Biokleen

              Biokleen has produced different cleaners to treat different pet accidents. Whether you choose products for your pets or domestic needs, such as bathroom cleaners, kitchen cleaners, and laundry, all of them are environment-friendly. So, you can rest your mind about their safety.

              Rug Doctor

              As the name suggests, this brand specializes in cleaners for rugs and carpets. So, any product of this brand can treat stains and odors on carpets and rugs effectively and safely without ruining their fibers.

              Nok Out

              Products from this brand are totally non-toxic, but they have different versions based on different needs. You can find odor eliminators and carpet cleaners for disinfectants both online and offline.

              Anti-Icky-Poo

              Their products are both scented and unscented options, so you always have at least an appropriate choice for dogs who don’t like scents and people who love pleasant odors.

              Pet Stain Off

              This brand has produced and sold cleaners and other products for treating pet accidents.

              The Clean Team

              The Clean Team enzymatic cleaners can solve both problems of pet accident stains and food stains.

              Simple Solution

              Simple Solution varies in environment-friendly stain and odor removals, so it’s safe to use.

              FAQs

              What is an enzymatic cleaner for dog urine?

              An enzymatic cleaner is a cleaning product that uses enzymes - macromolecular biological catalysts - to speed up chemical reactions and break down stains.

              Do you need an enzymatic cleaner for dog urine?

              Any dog owner should buy one enzymatic cleaner for dog urine to keep their whole house clean because dogs can cause an accident anytime. And you need to handle their messes as soon as possible. The longer you leave the stains on the surface, the harder you must remove it.

              How do enzymatic cleaners work?

              The enzymatic cleaner contains beneficial bacteria that break down molecules in organic materials such as food, fences, especially urine. After enzymes break molecules down into small pieces, bacteria will consume them, leaving a clean surface.

              Are enzymatic cleaners effective?

              They are effective if you apply the right cleaner for the right type of stains. The different products are formulated for different stain types. If you use a weak solution for an obstinate stain, your purchase is useless. On the contrary, a too powerful product can ruin a delicate surface. For example, some work well for odor only while others can remove both odors and stains.

              Are enzymatic cleaners safe for dogs?

              Yes. All products on the market are safe for dogs because enzymatic cleaners are non-toxic and biodegradable solutions that won’t harm your pet when touching accidentally.

              However, make sure to choose and buy your enzymatic cleaner from a reliable shop or website.

              Conclusion

              The best enzymatic cleaner for dog urine allows you to remove dog urine stains and odors effectively. If your dog’s accidents are old and you can’t see the improvement on the first application, you can try a few times. Although this type of cleaner is not as powerful as a chemical cleaner, it can handle your problem sooner or later.

              Moreover, this choice is totally safe for your lovely pet and safety is the top priority of any pet owner, right?


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